S Kraguljac NV, Montori VM, Pavuluri M, Chai HS, Wilson BS, Unal SS (2009) Efficacy of omega-3 Fatty acids in mood disorders - a systematic review and metaanalysis. Psychopharmacology Bulletin 42(3):39-54
These latter results could be of importance because the mechanisms they suggest appear to be dose-dependent, a crucial characteristic to explain the dose-dependent effects of glucose.
(1986) Glucose effects on memory: behavioral and ..
A number of peripheral mechanisms have been proposed, including the possibility that glucose-sensitive neurons in the brain or in the periphery may serve as glucose sensors and eventually produce neural changes that would facilitate memory processing.
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Hyperglycemia is common in acutely ill patients, including those treated in intensive care units (ICUs). The occurrence of hyperglycemia, in particular severe hyperglycemia, is associated with increased morbidity and mortality in a variety of groups of patients, but trials examining the effects of tighter glucose control have had conflicting results. Systematic reviews and meta-analyses have also led to differing conclusions. Nevertheless, many professional organizations recommend tight glucose control for patients treated in ICUs.
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Of the 6104 patients who underwent randomization, 3054 were assigned to undergo intensive control and 3050 to undergo conventional control; data with regard to the primary outcome at day 90 were available for 3010 and 3012 patients, respectively. The two groups had similar characteristics at baseline. A total of 829 patients (27.5%) in the intensive-control group and 751 (24.9%) in the conventional-control group died (odds ratio for intensive control, 1.14; 95% confidence interval, 1.02 to 1.28; P=0.02). The treatment effect did not differ significantly between operative (surgical) patients and nonoperative (medical) patients (odds ratio for death in the intensive-control group, 1.31 and 1.07, respectively; P=0.10). Severe hypoglycemia (blood glucose level, ≤40 mg per deciliter [2.2 mmol per liter]) was reported in 206 of 3016 patients (6.8%) in the intensive-control group and 15 of 3014 (0.5%) in the conventional-control group (P
Cinnamon has been shown to help lower blood glucose levels
But evidence has been emerging for several years now, indicating that phosphatidylserine derived from plant sources, such as soybean lecithin, may be equally effective and safer than that derived from animal brain sources.In 1990, a two-month treatment study using plant-derived soybean phosphatidylserine showed positive effects on daily functioning, emotional state and self-reported general condition of Alzheimer's disease patients.A team of Tokyo scientists compared both the composition and pharmacological properties of phosphatidylserine prepared from soybean lecithin with those of bovine cortex source phosphatidylserine to improve cognitive disorders of senile dementia patients.
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With advancing age, however, the HPAA suffers decline and dysfunction, which can affect mood.Evidence has been emerging for several years now, indicating that phosphatidylserine derived from plant sources, such as soybean lecithin, may be equally effective and safer than that derived from animal brain sources.An earlier study by the same research team, which examined physical stress response more specifically, illustrated that phosphatidylserine could offset the body's response to physical stress as shown by a marked decrease in stress hormones.