Ebola Map | Virus & Contagious Disease Surveillance

This study demonstrates the emergence of EBOV in Guinea. The high degree of similarity among the 15 partial L gene sequences, along with the three full-length sequences and the epidemiologic links between the cases, suggest a single introduction of the virus into the human population. This introduction seems to have happened in December 2013. Further epidemiologic investigation is ongoing to identify the presumed animal source of the outbreak. It is suspected that the virus was transmitted for months before the outbreak became apparent because of clusters of cases in the hospitals of Guéckédou and Macenta. This length of exposure appears to have allowed many transmission chains and thus increased the number of cases of Ebola virus disease.

4. Centers for Disease Control and Prevention. Ebola outbreaks 2000-2014. 2014 ().

Previous experience with EVD outbreaks, though they have been limited in size and geographic spread, suggests that transmission can be interrupted, and case incidence reduced, within 2 to 3 weeks after the introduction of control measures. This view is reinforced by the estimates of case reproduction number presented in this analysis. We estimate the 0 to have varied between 1.71 (upper boundary of the 95% confidence interval, 2.01) in Guinea to 2.02 (upper boundary of the 95% confidence interval, 2.26) in Sierra Leone. This means that transmission has to be a little more than halved to achieve control of the epidemic and eventually to eliminate the virus from the human population. Considering the prospects for a novel Ebola vaccine, an immunization coverage exceeding 50% would have the same effect. Greater reductions in transmission would, of course, be desirable, but minimum requirements for the containment of EVD are far less severe than for the containment of more contagious diseases, such as measles. Between March and July 2014, the reproduction number in Guinea fluctuated around the threshold value of 1, suggesting that modest further intervention efforts at that point could have achieved control.


A Virus Mutation Is What Made The 2014 Ebola Outbreak …

Emergence of Zaire Ebola Virus Disease in Guinea | NEJM

Shown are transmission chains in the Ebola virus disease outbreak involving laboratory-confirmed cases. The presumed means of transmission of (EBOV), as revealed by epidemiologic investigation, are indicated by solid arrows. Dashed arrows indicate that the epidemiologic links are not well established. Laboratory-confirmed cases (C) are indicated with red circles, and suspected cases (S) are indicated with the case number. The inset image is an electron microscopic scan of the Guinean strain of EBOV in blood obtained from a patient. A typical complete virus particle, with the ends marked by arrows, and two degraded particles (arrowheads) are shown.


Ebola Outbreak - 2018 News and Scientific Articles on …

Shown are transmission chains in the Ebola virus disease outbreak involving laboratory-confirmed cases. The presumed means of transmission of (EBOV), as revealed by epidemiologic investigation, are indicated by solid arrows. Dashed arrows indicate that the epidemiologic links are not well established. Laboratory-confirmed cases (C) are indicated with red circles, and suspected cases (S) are indicated with the case number. The inset image is an electron microscopic scan of the Guinean strain of EBOV in blood obtained from a patient. A typical complete virus particle, with the ends marked by arrows, and two degraded particles (arrowheads) are shown.

Ebola outbreak - The New York Times

Although the current epidemic of EVD in West Africa is unprecedented in scale, the clinical course of infection and the transmissibility of the virus are similar to those in previous EVD outbreaks. The incubation period, duration of illness, case fatality rate, and 0 are all within the ranges reported for previous EVD epidemics. Our estimates of 0 are similar to other recent estimates for this West Africa epidemic. The combination of signs and symptoms recorded between symptom onset and clinical presentation is also similar to that in other reports. We infer that the present epidemic is exceptionally large, not principally because of the biologic characteristics of the virus, but rather because of the attributes of the affected populations and because control efforts have been insufficient to halt the spread of infection.

If contracted, Ebola is one of the world’s most deadly diseases

5. Sanchez A, Ksiazek TG, Rollin PE, et al. Detection and molecular characterization of Ebola viruses causing disease in human and nonhuman primates. ;179::-